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Tuesday, January 15, 2019

2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside may be beneficial for Alzheimer's disease prevention and treatment.

PMID:  Biochem Biophys Res Commun. 2018 01 1 ;495(1):672-678. Epub 2017 Nov 9. PMID: 29129695 Abstract Title:  Tetrahydroxystilbene glucoside modulates amyloid precursor protein processing via activation of AKT-GSK3β pathway in cells and in APP/PS1 transgenic mice. Abstract:  Alternative splicing of amyloid precursor protein (APP) exon 7 generates the isoforms containing a Kunitz protease inhibitor (KPI) domain. APP-KPI levels in the brain are correlated with amyloid beta (Aβ) production. Here, we determined the effect of Tetrahydroxystilbene glucoside (TSG) on the AKT-GSK3β pathway. We found GSK3β increased APP-KPI inclusion level and interacted with the splicing factor ASF. TSG was intragastrically administered to 5-month-old APP/PS1 transgenic mice for 12 months.We found that the activated the AKT-GSK3β signaling pathway suppressed APP-KPI inclusion. Moreover, TSG treatment attenuated amyloid deposition in APP/PS1 mice. This study demonstrates the neuroprotective effect of TSG on APP expression, suggesting that TSG may be beneficial for AD prevention andtreatment.

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from GreenMedInfo http://bit.ly/2TRsyw4

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