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Monday, January 14, 2019

Blackcurrant anthocyanins has the potential to be developed to treat neurological conditions with IGF-1 deficiency.

PMID:  Nutrients. 2018 Jun 2 ;10(6). Epub 2018 Jun 2. PMID: 29865234 Abstract Title:  Supplementation of Blackcurrant Anthocyanins Increased Cyclic Glycine-Proline in the Cerebrospinal Fluid of Parkinson Patients: Potential Treatment to Improve Insulin-Like Growth Factor-1 Function. Abstract:  BACKGROUND: Insulin-like growth factor-1 (IGF-1) function is impaired in Parkinson disease. Cyclic glycine-proline (cGP), a metabolite of IGF-1, is neuroprotective through improving IGF-1 function. Parkinson disease patients score lower on Hospital-associated Anxiety and Depression Scale after supplementing blackcurrant anthocyanins (BCA), which may be associated with IGF-1 function. We evaluated the changes of cGP and IGF-1 before and after the supplementation.METHODS: Plasma and cerebrospinal fluid (CSF) were collected from 11 male patients before and after 28 day supplementation of BCA. The concentrations of IGF-1, IGF binding protein (IGFBP)-3, and cGP were measured using ELISA and HPLC-MS assays. The presence of cGP in the BCA was evaluated.RESULTS: cGP presented in the BCA. BCA supplementation increased the concentration of cGP (

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from GreenMedInfo http://bit.ly/2RT6GDj

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