Featured Posts

Saturday, January 12, 2019

Guarana hydroalcoholic extract has therapeutic potential in combating age-related diseases associated with protein misfolding and accumulation.

PMID:  Oxid Med Cell Longev. 2018 ;2018:9241308. Epub 2018 Jul 4. PMID: 30116496 Abstract Title:  Guarana () Extract ProtectsModels for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways. Abstract:  Guarana () is largely consumed in Brazil in high energy drinks and dietary supplements because of its stimulant activity on the central nervous system. Although previous studies have indicated that guarana has some protective effects in Parkinson's (PD), Alzheimer's (AD), and Huntington's (HD) disease models, the underlying mechanisms are unknown. Here, we investigated the protective effects of guarana hydroalcoholic extract (GHE) inmodels of HD and AD. GHE reduced polyglutamine (polyQ) protein aggregation in the muscle and also reduced polyQ-mediated neuronal death in ASH sensory neurons and delayed-amyloid-induced paralysis in a caffeine-independent manner. Moreover, GHE's protective effects were not mediated by caloric restriction, antimicrobial effects, or development and reproduction impairment. Inactivation of the transcription factors SKN-1 and DAF-16 by RNAi partially blocked the protective effects of GHE treatment in the AD model. We show that the protective effect of GHE is associated with antioxidant activity and modulation of proteostasis, since it increased the lifespan and proteasome activity, reduced intracellular ROS and the accumulation of autophagosomes, and increased the expression of SOD-3 and HSP-16.2. Our findings suggest that GHE has therapeutic potential in combating age-related diseases associated with protein misfolding and accumulation.

read more



from GreenMedInfo http://bit.ly/2VLSM4Q

No comments:

Post a Comment