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Friday, January 11, 2019

Prevalence of vitamin K deficiency in hip fracture patients is high and increases further following a short period of fasting.

PMID:  Acta Clin Belg. 2019 Jan 8:1-5. Epub 2019 Jan 8. PMID: 30618350 Abstract Title:  Prevalence of vitamin K deficiency in older people with hip fracture. Abstract:  INTRODUCTION: Vitamin K plays an important role in blood coagulation. Diet is the main source of vitamin K and body stores are depleted in days, hence deficiency is common in malnourished older people. A high proportion of people who sustain a hip fracture are already malnourished, compounded by fasting for surgery which might further increase deficiency. We wanted to explore the prevalence of vitamin K deficiency in hip fracture patients and the impact of a short period of fasting.METHODS: In consecutive patients hospitalised with a hip fracture, we measured vitamin K and PIVKA-II (undercarboxylated factor II - a marker of subclinical vitamin K status) on admission and on first post-operative day. We excluded those on anticoagulants.RESULTS: N = 62 participated; 4 had missing pre-op vitamin K samples and n = 3 had no surgery leaving n = 55 with paired samples. Mean age was 80.0 ± 9.6 years, 33% males. Prevalence of subclinical vitamin K deficiency on admission was 36% (20/55) based on reference range of>0.15µg/L. The proportion with subclinical K deficiency after surgery rose to 64% (35/55), p 

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from GreenMedInfo http://bit.ly/2H7m4ro

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