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Friday, January 11, 2019

Thymoquinone attenuates hepatotoxicity and oxidative damage caused by diazinon.

PMID:  Res Pharm Sci. 2018 Dec ;13(6):500-508. PMID: 30607148 Abstract Title:  Thymoquinone attenuates hepatotoxicity and oxidative damage caused by diazinon: anstudy. Abstract:  Thymoquinone (TQ) is the main active constituent ofseeds. The objective of this study was to explore the protective effects of TQ on diazinon (DZN)-induced liver toxicity in the mouse model. The animals were divided into five groups of 6 each and treated intraperitoneally. Group 1 received the vehicle, group 2 was given 16 mg/kg DZN, group 3 received 5 mg/kg TQ, and groups 4 and 5 were treated with 1.25 and 5 mg/kg of TQ as well as 16 mg/kg DZN, respectively. Finally, butyrylcholinesterase (BChE), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) serum activity as well as nitric oxide (NO), lipid peroxidation (LPO), total antioxidant capacity (TAC), total thiol molecule (TTM), and histopathological experiments were evaluated in the liver samples. Our findings showed that DZN caused a significant increase in ALT (

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from GreenMedInfo http://bit.ly/2FkPIaL

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