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Monday, February 11, 2019

Administration of Zataria multiflora extract and carvacrol could reduce the oxidative damage in the rat liver induced by doxorubicin.

PMID:  Biomed J. 2018 Dec ;41(6):340-347. Epub 2019 Jan 11. PMID: 30709575 Abstract Title:  Effects of standardized Zataria multiflora extract and its major ingredient, Carvacrol, on Adriamycin-induced hepatotoxicity in rat. Abstract:  BACKGROUND: Due to antioxidant effects of Zataria multiflora (ZM) and Carvacrol (CAR) in many cases and the prominent role of reactive oxygen species (ROS) in hepatotoxicity induced by Adriamycin (ADR), the aim of this study is to investigate the effects of ZM and CAR on ADR-induced hepatotoxicity.METHODS: Twenty four male Wistar rats were randomly divided into four groups including: 1)Control, 2)Adriamycin (ADR), 3,4) ZM + ADR and CAR + ADR that received ZM and CAR for 28 consecutive days. Blood samples were collected on the days 0, 14 and 28 to determine the alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Also, the hepatic redox markers were evaluated.RESULTS: ADR significantly increased ALP, ALT and AST in comparison with the control (p 

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from GreenMedInfo http://bit.ly/2tjjpko

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