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Wednesday, February 13, 2019

Fructose-induced hypertriglyceridemia in rhesus macaques is attenuated with fish oil or apoC3 RNA interference.

PMID:  J Lipid Res. 2019 Feb 5. Epub 2019 Feb 5. PMID: 30723097 Abstract Title:  Fructose-induced hypertriglyceridemia in rhesus macaques is attenuated with fish oil or apoC3 RNA interference. Abstract:  Dyslipidemia and insulin resistance are significant adverse outcomes of consuming high-sugar diets. Conversely, dietary fish oil reduces plasma lipids. Diet-induced dyslipidemia in a rhesus model better approximates the pathophysiology of human metabolic syndrome than rodent models. Here we investigated relationships between metabolic parameters and hypertriglyceridemia in rhesus macaques consuming a high fructose diet (n=59) and determined effects of fish oil supplementation or RNA interference (RNAi) on plasma apoC3 and TG concentrations. Fructose supplementation increased body weight, fasting insulin, leptin, TGs, and large VLDL particles and reduced adiponectin concentrations (all p

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from GreenMedInfo http://bit.ly/2TLIwYX

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