Naringenin inhibited the migration and invasion of PC-3 cells.

PMID:  Anticancer Res. 2018 Dec ;38(12):6753-6758. PMID: 30504386 Abstract Title:  Naringenin Attenuated Prostate Cancer InvasionReversal of Epithelial-to-Mesenchymal Transition and Inhibited uPA Activity. Abstract:  BACKGROUND: Prostate cancer is highly prevalent with a high mortality among males worldwide. Naringenin has been demonstrated to exhibit multiple cellular functions. In this study, we examined the effects of naringenin on prostate cancer.MATERIALS AND METHODS: Transwell and zymography assays were used to detect cell migration and urokinase plasminogen activator (uPA) activity, respectively. Alternation of protein expression was measured by western blot analysis.RESULTS: Transwell assay and zymography revealed that naringenin suppressed the migration and invasion of PC-3 cells and uPA activity in proportion to the concentration of naringenin. Western blot analysis indicated that naringenin up-regulated E-cadherin expression, but down-regulated the expression of vimentin, SNAIL family zinc finger 1 (SNAI1), SNAIL family zinc finger 2 (SNAI2), and TWIST family bHLH transcription factor 1 (TWIST1).CONCLUSION: Naringenin inhibited the migration and invasion of PC-3 cells by reversing expression of proteins involved in epithelial-to-mesenchymal transition and down-regulation of uPA activity. Thus, naringenin may be a promising anti-metastasis agent for prostate cancer.

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