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Wednesday, February 6, 2019

Probiotics ingestion induces a less inflammatory cytokine profile and a potentially beneficial shift in gut microbiota in older adults.

PMID:  J Am Coll Nutr. 2015 ;34(6):459-69. Epub 2015 Apr 24. PMID: 25909149 Abstract Title:  Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2 Ingestion Induces a Less Inflammatory Cytokine Profile and a Potentially Beneficial Shift in Gut Microbiota in Older Adults Abstract:  OBJECTIVE: This study determined whether older adults who consumed a probiotic mixture would have a greater proportion of circulating CD4+ lymphocytes, altered cytokine production, and a shift in intestinal microbiota toward a healthier microbial community.METHODS: Participants (70± 1 years [mean ± SEM]; n = 32) consumed a probiotic (Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM2) or a placebo twice daily for 3 weeks with a 5-week washout period between intervention periods. Blood and stools were collected before and after each intervention. The percentage of circulating CD4+ lymphocytes and ex vivo mitogen-stimulated cell cytokine production were measured. In stools, specific bacterial targets were quantified via quantitative polymerase chain reaction (qPCR) and community composition was determined via pyrosequencing.RESULTS: During the first period of the crossover the percentage of CD4+ cells decreased with the placebo (48%± 3% to 31% ± 3%, p

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from GreenMedInfo http://bit.ly/2SwNqM3

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