Featured Posts

Wednesday, February 13, 2019

The roles of valerenic acid on BDNF expression in the SH-SY5Y cell.

PMID:  Saudi Pharm J. 2018 Nov ;26(7):960-964. Epub 2018 Jun 8. PMID: 30416353 Abstract Title:  The roles of valerenic acid on BDNF expression in the SH-SY5Y cell. Abstract:  The roots ofL. (Valerianaceae) are used for treating sleep disorders and/or mild nerve tension. The effect of valerenic acid on brain-derived neurotrophic factor (BDNF) has not yet been studied, although it is known that gamma-amino butyric acid A (GABA) receptor is regulated by BDNF, which modulates the depressive-like behavior and neurogenesis. The purpose of this study is to determine the effect ofroot extract (VO), its main constituents valerenic acid (VA) and acetoxy valerenic acid (AVA) as well as valerenic acid-free (VAF), acetoxy valerenic acid-free (AVAF) extracts and increasing amounts of valerenic acid containing extracts on the BDNF expression in SH-SY5Y cell lines. The effect of methanolic extracts of VO, VA, AVA, VAF, AVAF, and the extracts whose amount of VA were increased gradually, were tested using a Human BDNF ELISA kit with 17-estradiol as a positive control. The VO and VA extracts caused a significant ( 

read more



from GreenMedInfo http://bit.ly/2UQGNBy

No comments:

Post a Comment