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Tuesday, February 12, 2019

These findings support monolaurin as a promising antifungal compound.

PMID:  Biol Pharm Bull. 2018 ;41(8):1299-1302. PMID: 30068882 Abstract Title:  In Vivo Antifungal Activity of Monolaurin against Candida albicans Biofilms. Abstract:  Monolaurin is a natural compound that has been known for its broad antimicrobial activities. We evaluate the antifungal activity of monolaurin against Candida albicans biofilms in vivo using a novel bioluminescent model to longitudinally monitor oral fungal infection. Oral fungal infection in vivo was performed using bioluminescent engineered C. albicans (SKCa23-ActgLUC) biofilms on Balb/c mice. The antifungal activity of monolaurin was determined by comparing three groups of mice (n=5/group): monolaurin, vehicle control, and positive control (nystatin). All mice were immunosuppressed with cortisone acetate and oral topical treatments were applied for 5 d. In vivo imaging system (IVIS) imaging was used to monitor the progression of infection over a 5-d period. Total photon flux and ex vivo microbiological analysis of the excised tongues were used to determine the overall fungal burden. Oral topical treatments of monolaurin have resulted in a significant decrease (p

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from GreenMedInfo http://bit.ly/2SqRNZW

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